Protein Details: Aquaporin-0

Protein ID

ICDB_Pro_0304

Protein Name

Aquaporin-0

Gene Name

MIP

Organism

Bos taurus (Bovine)

Length

263 amino acids

AlphaFoldDB

AF-P06624-F1-model_v4.pdb

Function

Water channel . Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling.

Sequence

MWELRSASFWRAICAEFFASLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPRLKSVSERLSILKGSRPSESNGQPEVTGEPVELKTQAL

PDB Structures

1YMG 2C32

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 149: "Important for water channel gating"; SITE 246: "Interaction with BFSP1"; SITE 250: "interaction with BFSP1";

Disease

Location

Major component of lens fiber gap junctions

DOI ID

10.1016/0092-8674(84)90190-9; 10.1016/0014-5793(85)81116-9; 10.1111/j.1432-1033.1990.tb15650.x; 10.1038/nsmb.2630; 10.1016/j.bbamem.2016.06.026; 10.1016/j.exer.2017.02.012; 10.1073/pnas.0405274101; 10.1016/j.jmb.2005.10.032

RefSeq

NP_776362.1